The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair

Zeynep D. Akdeniz, Mehmet Bayramiçli, Filiz Ateş, Naziye Özkan, Can A. Yucesoy, Feriha Ercan

研究成果: Article

5 引用 (Scopus)

抄録

Introduction: The aim of this study was to test the hypothesis that the increased number of new motor endplates induced by botulinum toxin type A (BTX-A) injection before nerve injury would be reinnervated after nerve repair, resulting in greater force generation. Methods: Thirty male Wistar rats were divided randomly into 3 groups: (1) controls; (2) a group with saline solution injection; and (3) a group with BTX-A injection into gastrocnemius muscle (BTX group). Thirty-six days after the injections the left sciatic nerve was divided and coapted in all groups. Eight weeks later, muscle forces were measured, and histological samples were collected. Results: No differences in the number of innervated endplates were found between the groups, but the number of denervated endplates was higher in the BTX group, as was the muscle tissue degeneration score. The BTX group showed distal muscle force measurements of up to 25.8% less compared with the control group. Conclusion: Although BTX-A injection increases the number of motor endplates, they are not functional.

元の言語English
ページ(範囲)412-418
ページ数7
ジャーナルMuscle and Nerve
52
発行部数3
DOI
出版物ステータスPublished - 2015 9 1
外部発表Yes

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Motor Endplate
Botulinum Toxins
Peripheral Nerves
Type A Botulinum Toxins
Injections
Muscles
Control Groups
Sciatic Nerve
Sodium Chloride
Wistar Rats
Skeletal Muscle
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology
  • Medicine(all)

これを引用

Akdeniz, Z. D., Bayramiçli, M., Ateş, F., Özkan, N., Yucesoy, C. A., & Ercan, F. (2015). The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair. Muscle and Nerve, 52(3), 412-418. https://doi.org/10.1002/mus.24555

The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair. / Akdeniz, Zeynep D.; Bayramiçli, Mehmet; Ateş, Filiz; Özkan, Naziye; Yucesoy, Can A.; Ercan, Feriha.

:: Muscle and Nerve, 巻 52, 番号 3, 01.09.2015, p. 412-418.

研究成果: Article

Akdeniz, ZD, Bayramiçli, M, Ateş, F, Özkan, N, Yucesoy, CA & Ercan, F 2015, 'The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair', Muscle and Nerve, 巻. 52, 番号 3, pp. 412-418. https://doi.org/10.1002/mus.24555
Akdeniz ZD, Bayramiçli M, Ateş F, Özkan N, Yucesoy CA, Ercan F. The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair. Muscle and Nerve. 2015 9 1;52(3):412-418. https://doi.org/10.1002/mus.24555
Akdeniz, Zeynep D. ; Bayramiçli, Mehmet ; Ateş, Filiz ; Özkan, Naziye ; Yucesoy, Can A. ; Ercan, Feriha. / The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair. :: Muscle and Nerve. 2015 ; 巻 52, 番号 3. pp. 412-418.
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abstract = "Introduction: The aim of this study was to test the hypothesis that the increased number of new motor endplates induced by botulinum toxin type A (BTX-A) injection before nerve injury would be reinnervated after nerve repair, resulting in greater force generation. Methods: Thirty male Wistar rats were divided randomly into 3 groups: (1) controls; (2) a group with saline solution injection; and (3) a group with BTX-A injection into gastrocnemius muscle (BTX group). Thirty-six days after the injections the left sciatic nerve was divided and coapted in all groups. Eight weeks later, muscle forces were measured, and histological samples were collected. Results: No differences in the number of innervated endplates were found between the groups, but the number of denervated endplates was higher in the BTX group, as was the muscle tissue degeneration score. The BTX group showed distal muscle force measurements of up to 25.8{\%} less compared with the control group. Conclusion: Although BTX-A injection increases the number of motor endplates, they are not functional.",
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