The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

Shigenobu Shibata; Akiko Shiratsuchi; Shyh Yuh Liou; Showa Ueki

doi:10.1016/0304-3940(84)90371-9

The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

Shigenobu Shibata^*, Akiko Shiratsuchi, Shyh Yuh Liou, Showa Ueki

^*この研究の対応する著者

研究成果 › 査読

36 被引用数 (Scopus)

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The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca²⁺ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca²⁺ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.

本文言語	English
ページ（範囲）	181-184
ページ数	4
ジャーナル	Neuroscience Letters
巻	52
号	1-2
DOI	https://doi.org/10.1016/0304-3940(84)90371-9
出版ステータス	Published - 1984 11 23
外部発表	はい

ASJC Scopus subject areas

神経科学（全般）

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10.1016/0304-3940(84)90371-9

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title = "The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices",

abstract = "The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca2+ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca2+ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.",

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author = "Shigenobu Shibata and Akiko Shiratsuchi and Liou, {Shyh Yuh} and Showa Ueki",

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T1 - The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

AU - Shibata, Shigenobu

AU - Shiratsuchi, Akiko

AU - Liou, Shyh Yuh

AU - Ueki, Showa

PY - 1984/11/23

Y1 - 1984/11/23

N2 - The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca2+ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca2+ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.

AB - The role of calcium ions in maintaining the circadian rhythm of suprachiasmatic nucleus (SCN) neuron activity was investigated using rat hypothalamic slice preparations. In normal Krebs solution, the firing rate of SCN neurons was higher in the light period than in the dark period. In Ca2+ -free Krebs solution, SCN neuron activity was low during all periods and did not show diurnal rhythm. These results suggest that the disappearance of circadian rhythmic change of SCN neuron activity in Ca2+ -free Krebs solution may be due to the disappearance of synaptic transmission in the SCN.

KW - calcium ions

KW - circadian rhythm

KW - rat brain slice

KW - single unit activity

KW - suprachiasmatic nucleus

KW - synaptic transmission

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The role of calcium ions in circadian rhythm of suprachiasmatic nucleus neuron activity in rat hypothalamic slices

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