The Role of Reactive Oxygen and Nitrogen Species in Skeletal Muscle

Zsolt Radak*, Erika Koltai

*この研究の対応する著者

研究成果: Chapter

抄録

Skeletal muscle is a very dynamic tissue with a large adaptive capacity and a remarkable resistance to reactive oxygen and nitrogen species (RONS). The reason for this resistance could be the fact that muscle contraction generates RONS, which, up to a certain extent, facilitate the power of contraction. Therefore, moderate levels of RONS appear to be beneficial to muscle function and fiber type differentiation via redox sensitive SIRT1 pathways through MyD and PGC1-alpha. Physiological levels of RONS are likely among those factors which play a role in mitochondrial biogenesis, and the unique subpopulation of mitochondria of skeletal muscle could be differentially affected by RONS. RONS are active, physiological stimulators of certain cellular processes in the skeletal muscle, which include the capacity of force generation, differentiation, and mitochondrial biogenesis. They are also involved in the regulation of antioxidant and oxidative damage-repair systems.

本文言語English
ホスト出版物のタイトルMuscle and Exercise Physiology
出版社Elsevier
ページ309-315
ページ数7
ISBN(電子版)9780128145944
ISBN(印刷版)9780128145937
DOI
出版ステータスPublished - 2018 11月 8
外部発表はい

ASJC Scopus subject areas

  • 農業および生物科学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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