The Roles of RFamide-related peptide-3 in mammalian reproductive function and behaviour

L. J. Kriegsfeld*, E. M. Gibson, W. P. Williams, S. Zhao, A. O. Mason, G. E. Bentley, Kazuyoshi Tsutsui

*この研究の対応する著者

    研究成果査読

    73 被引用数 (Scopus)

    抄録

    To maximise reproductive success, organisms restrict breeding to optimal times of the day or year, when internal physiology and external environmental conditions are suitable for the survival of both parent and offspring. To appropriately coordinate reproductive activity, internal and external standing is communicated to the hypothalamic-pituitary-gonadal axis via a coordinated balance of stimulatory and inhibitory neurochemical systems. The cumulative balance of these mediators ultimately drives the pattern of gonadotrophin-releasing hormone secretion, a neurohormone that stimulates pituitary gonadotrophin secretion. Until 2000, a complementary inhibitor of pituitary gonadotrophin secretion had not been identified. At this time, a novel, avian hypothalamic peptide capable of inhibiting gonadotrophin secretion in cultured quail pituitary cells was uncovered and named gonadotrophin-inhibitory hormone (GnIH). Subsequently, the presence and functional role for the mammalian orthologue of GnIH, RFamide-related peptide, (RFRP-3), was examined, confirming a conserved role for this peptide across several rodent species. To date, a similar distribution and functional role for RFRP-3 have been observed across all mammals investigated, including humans. This overview summarises the role that RFRP-3 plays in mammals and considers the implications and opportunities for further study with respect to reproductive physiology and the neural control of sexual behaviour and motivation.

    本文言語English
    ページ(範囲)692-700
    ページ数9
    ジャーナルJournal of Neuroendocrinology
    22
    7
    DOI
    出版ステータスPublished - 2010 7

    ASJC Scopus subject areas

    • 内分泌学
    • 内分泌学、糖尿病および代謝内科学
    • 内分泌系および自律システム
    • 細胞および分子神経科学

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