Theoretical design of monofunctional psoralen compounds in photochemotherapy

Ayako Nakata, Takeshi Baba, Hiromi Nakai

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The geometries and electronic structures in the lowest triplet (T 1) states of psoralen, 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and their monoadducts were studied by performing density functional theory (DFT) calculations. It was shown that the pyrone ring of 8-MOP is cleaved in the T1 state and the cleaved pyrone ring loses the ability to bond to the thymine residue. Therefore, 8-MOP in the open-ring structure does not form a diadduct, which is thought to cause side effects. DFT calculations on 20 kinds of substituted psoralens showed that the cleavage of the pyrone ring in the T1 state can be controlled by substituting an electron-donating group, especially one having a strong electron-donating resonance effect, at the 8-position of psoralen.

本文言語English
ページ(範囲)1341-1349
ページ数9
ジャーナルBulletin of the Chemical Society of Japan
80
7
DOI
出版ステータスPublished - 2007 12 1

ASJC Scopus subject areas

  • Chemistry(all)

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