Theoretical prediction and atomic force microscope observations of the protein nanotube consisting of homo-L-amino acid penta-peptide nanorings

Hajime Okamoto, Tsutomi Nakanishi, Yukiko Nagai, Kyozaburo Takeda, Ikuo Obataya, Hisakazu Mihara, Hiroaki Azehara, Wataru Mizutani

研究成果: Article査読

10 被引用数 (Scopus)

抄録

An unusual penta-peptide nanotube was synthesized by a solid-phase method using Fmoc chemistry. This nanotube consists of the natural homo-L-amino acid sequence (cyclo[-(L-Gln)5]), which is different from the already-known DL-peptide nanotubes having an even number of residues. We also observed the morphology by atomic force microscope (AFM) and found meandering tubular structures on the substrate. This result is consistent with our ab initio energy calculations, which show that the penta-peptide nanorings stabilize by breaking the C5 symmetry and stack themselves to form a meandering nanotube through the inter-ring hydrogen bonds.

本文言語English
ページ(範囲)676-679
ページ数4
ジャーナルJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
42
2 A
DOI
出版ステータスPublished - 2003 2

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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