Thiol-Michael ‘click’ hydrogels as an imageable packing material for cancer therapy

Nicholas G. Moon, Allison M. Pekkanen, Timothy Edward Long, Timothy N. Showalter, Bruce Libby*

*この研究の対応する著者

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Gynecological cancer treatment strategies commonly employ pelvic brachytherapy, a technique that temporarily locates radioactive materials in or near the source of the tumor. Despite numerous advances in brachytherapy treatment protocols, advances in the required vaginal packing materials lag significantly. This paper describes a packing material for vaginal brachytherapy based on a poly(ethylene glycol) (PEG)-based hydrogel. Commercially available oligomeric starting materials rapidly formed a hydrogel upon action of mild base (NaHCO3) through a thiol-Michael addition reaction. Tuning the base concentration enabled rapid formation of hydrogels with moduli sufficient for effective tissue displacement (>10 kPa). The poly(ethylene glycol) diacrylate oligomer molecular weight exerted minimal influence on the hydrogel modulus. The hydrogels absorbed up to four times their weight in water from the dry state. CT imaging demonstrated distinguishability between hydrogel, water, and metal medical tools. The hydrogels did not induce significant IL-8 upregulation or cytotoxicity when cultured against vaginal macrophage cells, suggesting lack of immunogenicity. Our findings support these hydrogels as ideal candidates for a packing material in pelvic brachytherapy applications.

本文言語English
ページ(範囲)66-75
ページ数10
ジャーナルPolymer (United Kingdom)
125
DOI
出版ステータスPublished - 2017 9 8
外部発表はい

ASJC Scopus subject areas

  • 有機化学
  • ポリマーおよびプラスチック

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