Thioporidiols a and b: Two new sulfur compounds discovered by molybdenum-catalyzed oxidation screening from trichoderma polypori FKI-7382

Hirotaka Matsuo*, Yoshihiko Noguchi, Rei Miyano, Mayuka Higo, Kenichi Nonaka, Toshiaki Sunazuka, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Two new sulfur compounds, designated thioporidiol A (1) and B (2), were discovered by the MoS-screening program from a culture broth of Trichoderma polypori FKI-7382. The structures of 1 and 2 were determined as C13 lipid structures with an N-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of 1 was determined by the derivatives of α-methoxy-α-phenylacetic acid diesters, and the absolute configuration of the N-acetylcysteine moiety was determined by advanced Marfey’s analysis. Compounds 1 and 2 were evaluated for anti-microbial, cytotoxic and anti-malarial activities. Compound 2 exhibited anti-microbial activity against Candida albicans ATCC 64548.

本文言語English
論文番号236
ジャーナルAntibiotics
9
5
DOI
出版ステータスPublished - 2020 5
外部発表はい

ASJC Scopus subject areas

  • 微生物学
  • 生化学
  • 薬理学、毒性学および薬学(全般)
  • 微生物学(医療)
  • 感染症
  • 薬理学(医学)

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