Three-dimensional architecture of human medial gastrocnemius fascicles in vivo: Regional variation and its dependence on muscle size

Katsuki Takahashi, Hiroto Shiotani, Pavlos E. Evangelidis, Natsuki Sado, Yasuo Kawakami*

*この研究の対応する著者

研究成果: Article査読

抄録

Fascicle architecture (length and pennation angle) can vary regionally within a muscle. The architectural variability in human muscles has been evaluated in vivo, but the interindividual variation and its determinants remain unclear. Considering that within-muscle non-uniform changes in pennation angle are associated with change in muscle size by chronic mechanical loading, we hypothesized that the regional variation in fascicle architecture is dependent on interindividual variation in muscle size. To test this hypothesis, we reconstructed fascicles three-dimensionally along and across the whole medial gastrocnemius in the right lower leg of 15 healthy adults (10 males and 5 females, 23.7 ± 3.3 years, 165.8 ± 8.3 cm, 61.9 ± 11.4 kg, mean ± standard deviation) in neutral ankle joint position with the knee fully extended, using magnetic resonance diffusion tensor imaging and tractography. The 3D-reconstructed fascicles arose from the deep aponeurosis with variable lengths and angles both in sagittal and coronal planes. The fascicle length was significantly longer in the middle (middle-medial: 52.4 ± 6.1 mm, middle-lateral: 52.0 ± 5.1 mm) compared to distal regions (distal-medial: 41.0 ± 5.0 mm, distal-lateral: 38.9 ± 3.6 mm, p < 0.001). The 2D pennation angle (angle relative to muscle surface) was significantly greater in distal than middle regions, and medial than lateral regions (middle-medial: 26.6 ± 3.1°, middle-lateral: 24.1 ± 2.3°, distal-medial: 31.2 ± 3.6°, distal-lateral: 29.2 ± 3.0°, p ≤ 0.017), while only a proximo-distal difference was significant (p < 0.001) for 3D pennation angle (angle relative to line of action of muscle). These results clearly indicate fascicle's architectural variation in 3D. The magnitude of regional variation evaluated as standard deviation across regions differed considerably among individuals (4.0–10.7 mm for fascicle length, 0.9–5.0° for 2D pennation angle, and 3.0–8.8° for 3D pennation angle), which was positively correlated with the muscle volume normalized to body mass (r = 0.659–0.828, p ≤ 0.008). These findings indicate muscle-size dependence of the variability of fascicle architecture.

本文言語English
ページ(範囲)1324-1335
ページ数12
ジャーナルJournal of Anatomy
241
6
DOI
出版ステータスPublished - 2022 12月
外部発表はい

ASJC Scopus subject areas

  • 解剖学
  • 生態、進化、行動および分類学
  • 組織学
  • 分子生物学
  • 発生生物学
  • 細胞生物学

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