Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line

Minami Yamada, Norio Komatsu*, Koji Okada, Takashi Kato, Hiroshi Miyazaki, Yasusada Miura

*この研究の対応する著者

研究成果査読

46 被引用数 (Scopus)

抄録

Thrombopoietin (TPO) is a cytokine which can support the proliferation and differentiation of megakaryocyte progenitor cells, and the maturation of megakaryocytes. We show here that mitogen-activated protein (MAP) kinases, Erk1 and Erk2, are involved in TPO signal transduction in the human TPO-dependent megakaryocytic cell line, UT-7/TPO. TPO induced tyrosine phosphorylation of Erk1 and Erk2 proteins in a dose and time-dependent manner. Moreover, the activation of MAP kinases was actually induced by TPO. These results suggest that MAP kinase activation is involved in the signalling pathway of TPO, as it is for other cytokines, one of which is erythropoietin.

本文言語English
ページ(範囲)230-237
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
217
1
DOI
出版ステータスPublished - 1995
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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