Thrombopoietin receptor (c-Mpl) is constitutively expressed on platelets of patients with liver cirrhosis, and correlates with its disease progression

Toru Ishikawa, Takafumi Ichida, Satoshi Sugahara, Satoshi Yamagiwa, Yasunobu Matsuda, Kazuhiro Uehara, Takashi Kato, Hiroshi Miyazaki, Hitoshi Asakura

研究成果: Article

10 引用 (Scopus)

抄録

Thrombocytopenia is one of the major complications of liver cirrhosis. Except for hypersplenism associated with portal hypertension, it is not known which abnormalities of thrombopoiesis cause thrombocytopenia. To evaluate thrombopoiesis in liver cirrhosis, we analyzed thrombopoietin (TPO) and its receptor c-Mp1 levels in cirrhotic patients. Expression of c-Mp1 on platelets and the serum level of TPO were investigated from 38 patients with various stages of liver cirrhosis by flow-cytometric analysis and enzyme-immuno assay. Samples obtained from 22 individuals without evidence of liver disease were used as controls. Neither platelet counts nor TPO levels correlated with disease progression defined by the Child-Pugh classification. c-Mp1 was constitutively expressed on the platelets of cirrhotic patients, and its expression level was reduced with disease progression defined by the Child-Pugh classification. In this study, serum TPO did not fluctuate according to the grade of cirrhosis. However, its receptor c-Mp1, which is expressed on platelets, was decreased significantly in severely cirrhotic patients with thrombocytopenia. Thus, a correlation between reduced c-Mp1 expression and the progression of liver cirrhosis was demonstrated. We conclude that, in addition to hypersplenism, the reduced expression of c-Mp1 may play a significant role in the thrombocytopenia observed in severe liver cirrhosis.

元の言語English
ページ(範囲)115-121
ページ数7
ジャーナルHepatology Research
23
発行部数2
DOI
出版物ステータスPublished - 2002 6 1
外部発表Yes

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Thrombopoietin Receptors
Liver Cirrhosis
Disease Progression
Thrombopoietin
Blood Platelets
Thrombocytopenia
Hypersplenism
Thrombopoiesis
Enzyme Assays
Portal Hypertension
Serum
Platelet Count
Liver Diseases
Fibrosis

ASJC Scopus subject areas

  • Gastroenterology

これを引用

Thrombopoietin receptor (c-Mpl) is constitutively expressed on platelets of patients with liver cirrhosis, and correlates with its disease progression. / Ishikawa, Toru; Ichida, Takafumi; Sugahara, Satoshi; Yamagiwa, Satoshi; Matsuda, Yasunobu; Uehara, Kazuhiro; Kato, Takashi; Miyazaki, Hiroshi; Asakura, Hitoshi.

:: Hepatology Research, 巻 23, 番号 2, 01.06.2002, p. 115-121.

研究成果: Article

Ishikawa, Toru ; Ichida, Takafumi ; Sugahara, Satoshi ; Yamagiwa, Satoshi ; Matsuda, Yasunobu ; Uehara, Kazuhiro ; Kato, Takashi ; Miyazaki, Hiroshi ; Asakura, Hitoshi. / Thrombopoietin receptor (c-Mpl) is constitutively expressed on platelets of patients with liver cirrhosis, and correlates with its disease progression. :: Hepatology Research. 2002 ; 巻 23, 番号 2. pp. 115-121.
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abstract = "Thrombocytopenia is one of the major complications of liver cirrhosis. Except for hypersplenism associated with portal hypertension, it is not known which abnormalities of thrombopoiesis cause thrombocytopenia. To evaluate thrombopoiesis in liver cirrhosis, we analyzed thrombopoietin (TPO) and its receptor c-Mp1 levels in cirrhotic patients. Expression of c-Mp1 on platelets and the serum level of TPO were investigated from 38 patients with various stages of liver cirrhosis by flow-cytometric analysis and enzyme-immuno assay. Samples obtained from 22 individuals without evidence of liver disease were used as controls. Neither platelet counts nor TPO levels correlated with disease progression defined by the Child-Pugh classification. c-Mp1 was constitutively expressed on the platelets of cirrhotic patients, and its expression level was reduced with disease progression defined by the Child-Pugh classification. In this study, serum TPO did not fluctuate according to the grade of cirrhosis. However, its receptor c-Mp1, which is expressed on platelets, was decreased significantly in severely cirrhotic patients with thrombocytopenia. Thus, a correlation between reduced c-Mp1 expression and the progression of liver cirrhosis was demonstrated. We conclude that, in addition to hypersplenism, the reduced expression of c-Mp1 may play a significant role in the thrombocytopenia observed in severe liver cirrhosis.",
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AU - Yamagiwa, Satoshi

AU - Matsuda, Yasunobu

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AU - Kato, Takashi

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AB - Thrombocytopenia is one of the major complications of liver cirrhosis. Except for hypersplenism associated with portal hypertension, it is not known which abnormalities of thrombopoiesis cause thrombocytopenia. To evaluate thrombopoiesis in liver cirrhosis, we analyzed thrombopoietin (TPO) and its receptor c-Mp1 levels in cirrhotic patients. Expression of c-Mp1 on platelets and the serum level of TPO were investigated from 38 patients with various stages of liver cirrhosis by flow-cytometric analysis and enzyme-immuno assay. Samples obtained from 22 individuals without evidence of liver disease were used as controls. Neither platelet counts nor TPO levels correlated with disease progression defined by the Child-Pugh classification. c-Mp1 was constitutively expressed on the platelets of cirrhotic patients, and its expression level was reduced with disease progression defined by the Child-Pugh classification. In this study, serum TPO did not fluctuate according to the grade of cirrhosis. However, its receptor c-Mp1, which is expressed on platelets, was decreased significantly in severely cirrhotic patients with thrombocytopenia. Thus, a correlation between reduced c-Mp1 expression and the progression of liver cirrhosis was demonstrated. We conclude that, in addition to hypersplenism, the reduced expression of c-Mp1 may play a significant role in the thrombocytopenia observed in severe liver cirrhosis.

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