Titin-based regulations of diastolic and systolic functions of mammalian cardiac muscle

Norio Fukuda, Takako Terui, Shin'ichi Ishiwata, Satoshi Kurihara

    研究成果: Article

    33 引用 (Scopus)

    抄録

    Titin is the largest protein in mammals; it forms an elastic filament along the myofibril of cardiac and skeletal muscles. Novel studies employing the recently available varied technologies have revealed the molecular mechanisms by which titin generates passive force in the sarcomere in response to external stretch. Changes in titin stiffness occur during heart disease via a shift in the expression ratio of the two main titin isoforms, called N2B (stiff type) and N2BA (compliant type) titins. Protein kinase (PK)A, PKG and PKC phosphorylate the cardiac specific I-band titin segment, resulting in an acute decrease (by PKA and PKG) or increase (by PKC) in passive force. It has also been discovered that titin performs roles that go beyond passive force generation, by enhancing or terminating active force production, thereby adjusting the Frank-Starling mechanism of the heart. Therefore, titin is a self-adjustable and multi-functional spring that is indispensable for proper heart functions. Here, we discuss how titin regulates the passive and active properties of cardiac muscle in normal physiological conditions as well as in chronic heart disease.

    元の言語English
    ページ(範囲)876-881
    ページ数6
    ジャーナルJournal of Molecular and Cellular Cardiology
    48
    発行部数5
    DOI
    出版物ステータスPublished - 2010 5

    Fingerprint

    Connectin
    Myocardium
    Heart Diseases
    Starlings
    Sarcomeres
    Myofibrils
    Cyclic AMP-Dependent Protein Kinases
    Mammals
    Protein Isoforms
    Skeletal Muscle
    Chronic Disease
    Technology

    ASJC Scopus subject areas

    • Molecular Biology
    • Cardiology and Cardiovascular Medicine

    これを引用

    Titin-based regulations of diastolic and systolic functions of mammalian cardiac muscle. / Fukuda, Norio; Terui, Takako; Ishiwata, Shin'ichi; Kurihara, Satoshi.

    :: Journal of Molecular and Cellular Cardiology, 巻 48, 番号 5, 05.2010, p. 876-881.

    研究成果: Article

    Fukuda, Norio ; Terui, Takako ; Ishiwata, Shin'ichi ; Kurihara, Satoshi. / Titin-based regulations of diastolic and systolic functions of mammalian cardiac muscle. :: Journal of Molecular and Cellular Cardiology. 2010 ; 巻 48, 番号 5. pp. 876-881.
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