Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

Nobuhiro Fusetani, Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest

研究成果: Article

26 引用 (Scopus)

抜粋

A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng / mL.

元の言語English
ページ(範囲)3397-3402
ページ数6
ジャーナルBioorganic and Medicinal Chemistry Letters
9
発行部数24
DOI
出版物ステータスPublished - 1999 12 20
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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