Topological Cluster Analysis Reveals the Systemic Organization of the Caenorhabditis elegans Connectome

Yunkyu Sohn, Myung Kyu Choi, Yong Yeol Ahn, Junho Lee, Jaeseung Jeong

研究成果: Article査読

38 被引用数 (Scopus)

抄録

The modular organization of networks of individual neurons interwoven through synapses has not been fully explored due to the incredible complexity of the connectivity architecture. Here we use the modularity-based community detection method for directed, weighted networks to examine hierarchically organized modules in the complete wiring diagram (connectome) of Caenorhabditis elegans (C. elegans) and to investigate their topological properties. Incorporating bilateral symmetry of the network as an important cue for proper cluster assignment, we identified anatomical clusters in the C. elegans connectome, including a body-spanning cluster, which correspond to experimentally identified functional circuits. Moreover, the hierarchical organization of the five clusters explains the systemic cooperation (e.g., mechanosensation, chemosensation, and navigation) that occurs among the structurally segregated biological circuits to produce higher-order complex behaviors.

本文言語English
論文番号e1001139
ジャーナルPLoS Computational Biology
7
5
DOI
出版ステータスPublished - 2011 5
外部発表はい

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • モデリングとシミュレーション
  • 生態学
  • 分子生物学
  • 遺伝学
  • 細胞および分子神経科学
  • 計算理論と計算数学

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