Total syntheses of polyketide-derived bioactive natural products

Kuniaki Tatsuta*, Seijiro Hosokawa

*この研究の対応する著者

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Recent progress of total syntheses in our laboratory has been described along with our background and methodologies. The target bioactive polyketides are classified into three categories according to their structures: (i) lactone-fused polycyclic compounds [(+)-cochleamycin A, (+)-tubelactomicin A, and (-)-tetrodecamycin], (ii) aromatic compounds [(-)-tetracycline, (-)-BE-54238B, lymphostin, and (-)-lagunamycin], and (iii) acyclic polyketides [xanthocillin X dimethylether, (+)-trichostatin D, and (+)-actinopyrone A]. Features of the total syntheses are described. Original methodologies have been developed and applied to construct the inherent structures of the target molecules. Most syntheses cited herein are the first total syntheses, and the absolute structures of the target molecules have been determined.

本文言語English
ページ(範囲)217-233
ページ数17
ジャーナルChemical Record
6
4
DOI
出版ステータスPublished - 2006 9 18

ASJC Scopus subject areas

  • 化学 (全般)
  • 生化学
  • 化学工学(全般)
  • 材料化学

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