Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Meng Zhao, Yi Xiao, Satoshi Otsuka, Yoichi Nakao, Yian Guo, Tao Ye

研究成果: Article査読

抄録

Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

本文言語English
論文番号410
ジャーナルFrontiers in Chemistry
8
DOI
出版ステータスPublished - 2020 5 13

ASJC Scopus subject areas

  • Chemistry(all)

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