Total synthesis and chemical biology of the sarcodictyins

K. C. Nicolaou*, Jeffrey Pfefferkorn, Jinyou Xu, Nicolas Winssinger, Takashi Ohshima, Sanghee Kim, Seijiro Hosokawa, Dionisios Vourloumis, Floris Van Delft, Tianhu Li

*この研究の対応する著者

研究成果: Review article査読

54 被引用数 (Scopus)

抄録

The sarcodictyins A - F and eleutherobin comprise a family of marine- derived diterpenoids with potent cytotoxicities against various tumor cell lines. Investigations have revealed that several of these compounds exert their cytotoxic effects through tubulin binding in a mechanism analogous to that of the clinical anticancer drug Taxol(TM). The biological importance, challenging molecular architecture, and relative scarcity of these natural products have prompted several groups to undertake their total chemical synthesis. In this review, we summarize the current synthetic efforts and examine the preliminary structure-activity relationships which have emerged from early combinatorial libraries.

本文言語English
ページ(範囲)1199-1213
ページ数15
ジャーナルChemical and Pharmaceutical Bulletin
47
9
DOI
出版ステータスPublished - 1999 9
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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