Total Synthesis and Structural Determination of XR774, a Tyrosine Kinase Inhibitor

Kuniaki Tatsuta, Daisuke Sekine, Shinichi Hayama, Yasuhiro Kataoka, Shinya Hayashi, Seijiro Hosokawa

研究成果: Article

抜粋

Total synthesis and structural determination of XR774 has been accomplished. The benzo[j]fluoranthene skeleton has been constructed by regioselective coupling between tetraline 3 and tetralone 4 successively followed by the sequential transformation including the Birch reduction to prepare allylic alcohol, simultaneous bromination of vinylic and aromatic moieties, and the nickel-mediated intramolecular coupling reaction. The optical resolution of racemic 17 led to the first total synthesis of (-)-XR774.

元の言語English
ページ(範囲)7010-7018
ページ数9
ジャーナルJournal of Organic Chemistry
83
発行部数13
DOI
出版物ステータスPublished - 2018 7 6

ASJC Scopus subject areas

  • Organic Chemistry

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