@article{cc53eb4ad34847758db25f438bd93669,
title = "Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol",
abstract = "A highly convergent synthesis was used to prepare a series of epimers and analogues of radicicol (1). Biological assessment revealed a previously unrecognized correlation between stereochemistry and antitumor potential in these compounds. Significantly, cycloproparadicicol (2) showed promising therapeutic properties based on inhibition of chaperones.",
keywords = "Antitumor agents, Chaperone proteins, Natural products, Structure-activity relationships, Synthesis design",
author = "Kana Yamamoto and Garbaccio, {Robert M.} and Stachel, {Shawn J.} and Solit, {David B.} and Gabriela Chiosis and Neal Rosen and Danishefsky, {Samuel J.}",
year = "2003",
month = mar,
day = "17",
doi = "10.1002/anie.200390329",
language = "English",
volume = "42",
pages = "1280--1284",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "11",
}