Total synthesis of an anti-Helicobacter pylori agent, actinopyrone A

Seijiro Hosokawa, Kazuya Yokota, Keisuke Imamura, Yasuaki Suzuki, Masataka Kawarasaki, Kuniaki Tatsuta

研究成果: Article

24 被引用数 (Scopus)

抄録

Actinopyrone A, an anti-Helicobacter pylori agent, was synthesized in nine steps from a silyl dienol ether. A vinylogous anti-aldol was stereoselectively synthesized by our developed remote stereoinduction methodology; coupling of this with a sulfone and a phosphonate species led to the construction of a vinylpyrone compound. This was submitted to reductive de-conjugation to give actinopyrone A. The absolute stereochemistry of actinopyrone A was determined to have the configuration 14R,15R.

本文言語English
ページ(範囲)1415-1421
ページ数7
ジャーナルChemistry - An Asian Journal
3
8-9
DOI
出版ステータスPublished - 2008 9 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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