Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Shijun Wen, Krystle L. Carey, Yoichi Nakao, Nobuhiro Fusetani, Graham Packham, A. Ganesan*

*この研究の対応する著者

研究成果: Article査読

52 被引用数 (Scopus)

抄録

(Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.

本文言語English
ページ(範囲)1105-1108
ページ数4
ジャーナルOrganic Letters
9
6
DOI
出版ステータスPublished - 2007 3 15
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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