Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Shijun Wen, Krystle L. Carey, Youichi Nakao, Nobuhiro Fusetani, Graham Packham, A. Ganesan

研究成果: Article

44 引用 (Scopus)

抜粋

(Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.

元の言語English
ページ(範囲)1105-1108
ページ数4
ジャーナルOrganic Letters
9
発行部数6
DOI
出版物ステータスPublished - 2007 3 15
外部発表Yes

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ASJC Scopus subject areas

  • Molecular Medicine

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