Total synthesis of (-)-bucidarasin a starting from an original chiral building block

Kenji Usui, Misaki Kanbe, Masahisa Nakada

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The highly stereoselective total synthesis of (-)-bucidarasin A, which also elucidated the absolute structure of its natural form, is described. The total synthesis features effective use of the original chiral building block prepared by us and a series of highly stereoselective reactions, i.e., hydroxydirected hydrogenation, [4 + 2] cycloaddition of a sterically hindered dienophile, reduction of ketones, formation of the C9 side-chain diene, and formation of the THF moiety bearing two acetyloxy groups.

本文言語English
ページ(範囲)4734-4737
ページ数4
ジャーナルOrganic Letters
16
18
DOI
出版ステータスPublished - 2014 9 19

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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