Total Synthesis of cis-Clavicipitic Acid from Asparagine via Ir-Catalyzed C-H bond Activation as a Key Step

Yu Ki Tahara, Mamoru Ito, Kyalo Stephen Kanyiva, Takanori Shibata*

*この研究の対応する著者

研究成果: Article査読

26 被引用数 (Scopus)

抄録

4-Substituted tryptophan derivatives and the total synthesis of cis-clavicipitic acid were achieved in reactions in which Ir-catalyzed C-H bond activation was a key step. The starting material for these reactions is asparagine, which is a cheap natural amino acid. The reductive amination step from the 4-substituted tryptophan derivative gave cis-clavicipitic acid with perfect diastereoselectivity.

本文言語English
ページ(範囲)11340-11343
ページ数4
ジャーナルChemistry - A European Journal
21
32
DOI
出版ステータスPublished - 2015 8 1

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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