Total synthesis of (-)-FR182877 through tandem IMDA-IMHDA reactions and stereoselective transition-metal-mediated transformations

Natsumi Tanaka, Takahiro Suzuki, Takehiko Matsumura, Yosuke Hosoya, Masahisa Nakada

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Intelligent design: The total synthesis of the cytotoxic (-)- FR182877 relies on 1) tandem Diels-Alder reactions to close rings A-D (see scheme), 2) a palladium-mediated 7- exo-trig reaction, and 3) an iridium-mediated isomerization followed by epimerization and stereoselective reduction.

本文言語English
ページ(範囲)2580-2583
ページ数4
ジャーナルAngewandte Chemie - International Edition
48
14
DOI
出版ステータスPublished - 2009 3 23

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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