Total synthesis of khafrefungin using highly stereoselective vinylogous Mukaiyama aldol reaction

Shin Ichi Shirokawa, Mariko Shinoyama, Isao Ooi, Seijiro Hosokawa, Atsuo Nakazaki, Susumu Kobayashi

研究成果: Article査読

48 被引用数 (Scopus)

抄録

(Chemical Equation Presented) A convergent total synthesis of khafrefungin was accomplished on the basis of (1) the highly stereoselective TiCl 4-mediated vinylogous Mukaiyama aldol reaction using vinylketene silyl N,O-acetal and (2) syn-selective aldol reaction of enal 5a and ethyl ketone 6 followed by anti-dehydration under Mitsunobu conditions.

本文言語English
ページ(範囲)849-852
ページ数4
ジャーナルOrganic Letters
9
5
DOI
出版ステータスPublished - 2007 3 1
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

フィンガープリント 「Total synthesis of khafrefungin using highly stereoselective vinylogous Mukaiyama aldol reaction」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル