Total Synthesis of PF1163B

Aakash Sengupta, Seijiro Hosokawa*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A total synthesis of PF1163B has been achieved. The vinylogous Mukaiyama aldol reaction of ketene silyl N, O -acetal 6 (ent - 6) mediated by excess TiCl 4 proceeded with saturated aldehydes to give adduct 10 in moderate yield with moderate stereoselectivity. The major isomer is the diastereomer that was provided by using one equivalent of TiCl 4. The Birch reduction of α,β-unsaturated imide 4, possessing a less hindered side chain, gave 12 in good stereoselectivity by employing 2-isopropylbenzimidazole as a bulky proton source. After elongation of the carbon chain and connection with the amino acid part, we accomplished a total synthesis of PF1163B. These methods constitute a concise synthetic route to obtain polyketides as well as depsipeptides.

本文言語English
ページ(範囲)709-712
ページ数4
ジャーナルSynlett
30
6
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 有機化学

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