抄録
A convergent stereocontrolled total synthesis of (+)-tautomycin (1), a specific inhibitor of protein serine/threonine phosphatases, has been achieved through an esterification of the C1.-C7. fragment A'74 with the C1-C26 fragment B'76 by a modified Yamaguchi method and an aldol reaction of the C17-C26 fragment C 5 with the C1-C16 fragment D 6 using LDA as key steps. The fragments 5 and 6 have been constructed in a stereocontrolled manner, respectively.
本文言語 | English |
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ページ(範囲) | 13363-13408 |
ページ数 | 46 |
ジャーナル | Tetrahedron |
巻 | 52 |
号 | 42 |
DOI | |
出版ステータス | Published - 1996 10月 14 |
外部発表 | はい |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学