Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives

Lauren E. Buerkle, Horst A. Von Recum, Stuart J. Rowan*

*この研究の対応する著者

研究成果: Article査読

65 被引用数 (Scopus)

抄録

We report the synthesis and study of a new guanosine-based hydrogelator, 8-methoxy-2′,3′,5′-tri-O-acetylguanosine, that can not only gel aqueous solutions at biologically relevant salt concentrations, but can also gel cell media. Studies suggest that this hydrogelator forms helical assemblies, rather than the macrocyclic quartet assemblies commonly found in guanosine hydrogels, which allow it to form hydrogels at as low as 0.5 wt% in 100mM NaCl. Furthermore, we show that this gelator is non-toxic to cells, injectable and that by simply mixing with 2′,3′,5′-tri-O- acetylguanosine, we can systematically vary the modulus and shear sensitivity of the gel over orders of magnitude.

本文言語English
ページ(範囲)564-572
ページ数9
ジャーナルChemical Science
3
2
DOI
出版ステータスPublished - 2012 2月
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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