Transcription factor Spi-B-dependent and-independent pathways for the development of Peyer's patch M cells

S. Sato, S. Kaneto, N. Shibata, Y. Takahashi, H. Okura, Y. Yuki, J. Kunisawa, H. Kiyono

研究成果: Article査読

76 被引用数 (Scopus)

抄録

Although many of the biological features of microfold cells (M cells) have been known for many years, the molecular mechanisms of M-cell development and antigen recognition have remained unclear. Here, we report that Umod is a novel M-cell-specific gene, the translation products of which might contribute to the uptake function of M cells. Transcription factor Spi-B was also specifically expressed in M cells among non-hematopoietic lineages. Spi-B-deficient mice showed reduced expression of most, but not all, other M-cell-specific genes and M-cell surface markers. Whereas uptake of Salmonella Typhimurium via M cells was obviously reduced in Spi-B-deficient mice, the abundance of intratissue cohabiting bacteria was comparable between wild-type and Spi-B-deficient mice. These data indicate that there is a small M-cell population with developmental regulation that is Spi-B independent; however, Spi-B is probably a candidate master regulator of M-cell functional maturation and development by another pathway.

本文言語English
ページ(範囲)838-846
ページ数9
ジャーナルMucosal Immunology
6
4
DOI
出版ステータスPublished - 2013 7
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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