Transcription Factors as Evolvable Biosensors

Daisuke Umeno, Yuki Kimura, Shigeko Kawai-Noma

研究成果: Article査読

抄録

One of the most prominent features of genetically encoded biosensors (GEBs) is their evolvability—the ability to invent new sensory functions using mutations. Among the GEBs, the transcription factor-based biosensors (TF-biosensors) is the focus of this review. We also discuss how this class of sensors can be highly evolvable and how we can exploit it. With an established platform for directed evolution, researchers can create, or evolve, new TF-biosensors. Directed evolution experiments have revealed the TF-biosensors’ evolvability, which is based partially on their characteristic physicochemical properties.

本文言語English
ページ(範囲)699-705
ページ数7
ジャーナルAnalytical Sciences
37
5
DOI
出版ステータスPublished - 2021 5
外部発表はい

ASJC Scopus subject areas

  • 分析化学

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