Transcription mechanism in a single neuron to control conditioned taste aversion in the pond snail lymnaea stagnalis

Etsuro Ito, Miki Yamagishi, Yusuke Yamagishi

研究成果: Chapter

抄録

Conditioned taste aversion (CTA) can be classically conditioned in the pond snail Lymnaea stagnalis and subsequently be consolidated into long-term memory (LTM). The neural mechanism that subserves CTA-LTM are summarized as follows: A polysynaptic inhibitory postsynaptic potential recorded in the neuron 1 medial (N1M) cell in the buccal ganglion of the conditioned snails as a result of activation of the cerebral giant cell (CGC) is larger and lasts longer than that in control snails. The N1M cell is the member of feeding central pattern generator, whereas the CGC is a multimodal interneuron thought to play a key role in the feeding behavior. The CGC is serotonergic and the secretion of setotonin from the CGC is controlled by cAMP, PKA and CREB, showing that these signaling cascades are involved in CTA. In this chapter we review the transcription mechanism, partuculary the cascades of cAMP-PKA-CREB and CCAAT/enhancer binding protein, in CTA-LTM.

本文言語English
ホスト出版物のタイトルMemory Consolidation
出版社Nova Science Publishers, Inc.
ページ111-126
ページ数16
ISBN(電子版)9781634826235
ISBN(印刷版)9781634825962
出版ステータスPublished - 2015 10 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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