Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510

Takuji Nakashima, Ryuki Okuyama, Yoshiyuki Kamiya, Atsuko Matsumoto, Masato Iwatsuki, Yuki Inahashi, Kenzaburo Yamaji, Yoko Takahashi, Satoshi Omura

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Three new natural products, designated trehangelins A, B and C, were isolated by solvent extraction, silica gel and octadecylsilyl silica gel column chromatographies and subsequent preparative HPLC from the cultured broth of an endophytic actinomycete strain, Polymorphospora rubra K07-0510. The trehangelins consisted of a trehalose moiety and two angelic acid moieties. Trehangelins A (IC 50 value, 0.1 mg ml -1) and C (IC 50 value, 0.4 mg ml -1), with symmetric structures, showed potent inhibitory activity against hemolysis of red blood cells induced by light-activated pheophorbide a. However, trehangelin B, with an asymmetric structure, displayed only a slight inhibition (IC 50 value, 1.0 mg ml -1).

本文言語English
ページ(範囲)311-317
ページ数7
ジャーナルJournal of Antibiotics
66
6
DOI
出版ステータスPublished - 2013 6
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

フィンガープリント

「Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル