Trends in the incidence of gastric cancer in Japan and their associations with Helicobacter pylori infection and gastric mucosal atrophy

Takanori Kobayashi, Shogo Kikuchi*, Yingsong Lin, Kiyoko Yagyu, Yuki Obata, Atsushi Ogihara, Ayako Hasegawa, Kazumasa Miki, Eizo Kaneko, Hiroshi Mizukoshi, Tsuguo Sakiyama, Hiroshi Tenjin

*この研究の対応する著者

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Background. Although age-adjusted mortality from gastric cancer has been decreasing in Japan, the crude incidence of gastric cancer shows a slight increase. Methods. We have observed trends in the incidence of gastric cancer by sex and 20-year age groups over the past two decades (1976-1996). Source data were obtained from the cancer statistics materials provided by the Research Group for Population-Based Cancer Registration in Japan. Simultaneously, we observed changes in the prevalence of Helicobacter pylori infection and in serological atrophy of the gastric mucosa, and compared the results with those involving changes hi the incidence of gastric cancer. Results. A slight decline was observed in all age groups over 40 years old, in both men and women, between 1986 and 1996. However, a marked decline in incidence was observed for those aged 20-39 years. The prevalence of H. pylori infection declined in both sexes between 1989 and 1998. The frequency of serological atrophy of the gastric mucosa significantly declined in all age groups between 1989 and 1996, with young age groups experiencing a more marked decrease. Conclusion. The marked decline in gastric cancer incidence observed in the young population will also begin to occur in the elderly population in the future.

本文言語English
ページ(範囲)233-239
ページ数7
ジャーナルGastric Cancer
7
4
DOI
出版ステータスPublished - 2004 12月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 消化器病学
  • 癌研究

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