Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-7573

Rei Miyano, Hirotaka Matsuo, Takayuki Mokudai, Yoshihiko Noguchi, Mayuka Higo, Kenichi Nonaka, Yoshimi Niwano, Toshiaki Sunazuka, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima*

*この研究の対応する著者

研究成果査読

2 被引用数 (Scopus)

抄録

A new nitrogen-containing compound, trichothioneic acid, was discovered from the metabolites of fungal strain FKI-7573 using a mass spectrometry screening method guided by odd number of molecular weights, which indicates compounds that contain an odd number of nitrogen atoms. Strain FKI-7573 was isolated from soil collected in Obihiro, Hokkaido, Japan, and identified as Trichoderma virens by a sequence analysis of the internal transcribed spacer region, including 5.8S ribosomal RNA. The structure of trichothioneic acid was determined by mass spectrometry, nuclear magnetic resonance spectroscopy, electronic circular dichroism spectra, and chemical degradation analyses. These analyses revealed that trichothioneic acid consists of heptelidic acid and L-ergothioneine, and contains three nitrogen atoms. Trichothioneic acid exhibited hydroxyl radical-scavenging and singlet oxygen-quenching activities.

本文言語English
ページ(範囲)508-513
ページ数6
ジャーナルJournal of Bioscience and Bioengineering
129
4
DOI
出版ステータスPublished - 2020 4
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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