Triple helical collagen-like peptides: Engineering and applications in matrix biology

研究成果: Review article査読

57 被引用数 (Scopus)

抄録

Collagen, a large insoluble protein with a characteristic triple helical structure, is found as the most prominent component of extracellular matrix. The functions of collagen are not limited to providing mechanical strength to various tissues and organs as a structural protein, as it has been pointed out that collagen exhibits various biological functions through specific interactions with other macromolecules. However, the use of native triple helical collagen is often troublesome because of its insolubility and gelating properties. Instead, triple helical collagen-like peptides have been designed and are used as collagen surrogates in studies on collagen structure, stability, and biological functions including binding to other proteins and cultured cells. This article reviews recent progress in peptide design, synthesis, and the applications of collagen-like peptides in current matrix biology, while emphasizing the advantages of the peptide-based strategy.

本文言語English
ページ(範囲)131-141
ページ数11
ジャーナルConnective Tissue Research
46
3
DOI
出版ステータスPublished - 2005
外部発表はい

ASJC Scopus subject areas

  • リウマチ学
  • 生化学
  • 整形外科およびスポーツ医学
  • 分子生物学
  • 細胞生物学

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