Tubular Network Formation by Mixing Amphiphilic Polypeptides with Differing Hydrophilic Blocks

Md Mofizur Rahman, Motoki Ueda, Kon Son, Siyoong Seo, Shinji Takeoka, Takuji Hirose, Yoshihiro Ito

研究成果: Article

抜粋

Artificial tubular networks are promising structures for biomaterial applications because of their large surface areas. A tubular network was formed by co-assembling two different amphiphilic polypeptides, poly(ethylene glycol)-b-(l-Leu-Aib)6 (PL12) and polysarcosine-b-(l-Leu-Aib)6 (SL12). They both have the same hydrophobic 12-mer helical block (l-Leu-Aib)6 but different hydrophilic chains, poly(ethylene glycol) and polysarcosine. In water, both polypeptides self-assembled into a tubular structure having a uniform 80 nm diameter that was formed by packing among the hydrophobic L12 blocks. The SL12 nanotubes were short (200 nm), straight, and robust. PL12 formed long (>1 μm), bendable, and fusogenic nanotubes. The amphiphiles were then co-assembled with various mixing ratios to form tubular networks. Higher concentrations of PL12 made the nanotubes more bendable and fusogenic between open tube ends, which produced branching junctions under heat treatment.

元の言語English
ジャーナルBiomacromolecules
DOI
出版物ステータスAccepted/In press - 2019 1 1

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

フィンガープリント Tubular Network Formation by Mixing Amphiphilic Polypeptides with Differing Hydrophilic Blocks' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用