Twice Stretched Fabrication of Polylactic Acid Microneedle Arrays Using Drawing Lithography

Shingo Terashima*, Chikako Tatsukawa, Masato Suzuki, Tomokazu Takahashi, Seiji Aoyagi

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A biodegradable poly-lactic acid (PLA) microneedle array composed of needles with a maximum length of 3 mm and an aspect ratio of up to approximately 18 was fabricated by drawing lithography. In the proposed fabrication method, the melted polymer is stretched twice. The approximate length is set in the first stretch, and the tip is sharpened in the second stretch. In the first stretch, by changing the thickness of the PLA sheet, PLA pillars with various lengths are fabricated. By defining the initial length of the needle, it is possible to set a wide range of aspect ratios and lengths. In the second stretch, it is possible to control the final aspect ratio and length of the needle, as well as the shape of its tip by changing the temperature and stretch speed of the PLA pillars. Finally, it was confirmed that the needle can pierce the surface of artificial skin and porcine skin.

本文言語English
ページ(範囲)1933-1942
ページ数10
ジャーナルInternational Journal of Precision Engineering and Manufacturing
21
10
DOI
出版ステータスPublished - 2020 10月 1
外部発表はい

ASJC Scopus subject areas

  • 機械工学
  • 産業および生産工学
  • 電子工学および電気工学

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