抄録
The sacoglossan mollusk Elysia rufescens elaborates six cyclic depsipeptides, kahalalides A- F. Its green algal diet (Bryopsis sp.) contains kahalalide G, which is an acyclic analogue of kahalalide F. Further analysis of the molluskan extract revealed two new acyclic peptides, kahalalide H (1) and kahalalide J (2), which share only four amino acids (leucine, phenylalanine, serine, and valine) with kahalalide F. Both contain aspartic acid and 4-hydroxyproline residues, and kahalalide J (2) also contains lysine. They have in common a β-hydroxy fatty acid, 3-hydroxy-9- methyldecanoic, previously encountered in kahalalide E. For kahalalide H (1) we succeeded in determining the sequential positions of the antipodal D- and L-phenylalanine. In common with the acyclic constituent of the alga, kahalalide G, the new compounds lack significant cytotoxicity.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 562-567 |
| ページ数 | 6 |
| ジャーナル | Journal of Natural Products |
| 巻 | 60 |
| 発行部数 | 6 |
| DOI | |
| 出版物ステータス | Published - 1997 6 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Organic Chemistry
- Drug Discovery
- Pharmacology
これを引用
Two acyclic kahalalides from the sacoglossan mollusk Elysia rufescens. / Goetz, Gilles; Nakao, Youichi; Scheuer, Paul J.
：: Journal of Natural Products, 巻 60, 番号 6, 06.1997, p. 562-567.研究成果: Article
}
TY - JOUR
T1 - Two acyclic kahalalides from the sacoglossan mollusk Elysia rufescens
AU - Goetz, Gilles
AU - Nakao, Youichi
AU - Scheuer, Paul J.
PY - 1997/6
Y1 - 1997/6
N2 - The sacoglossan mollusk Elysia rufescens elaborates six cyclic depsipeptides, kahalalides A- F. Its green algal diet (Bryopsis sp.) contains kahalalide G, which is an acyclic analogue of kahalalide F. Further analysis of the molluskan extract revealed two new acyclic peptides, kahalalide H (1) and kahalalide J (2), which share only four amino acids (leucine, phenylalanine, serine, and valine) with kahalalide F. Both contain aspartic acid and 4-hydroxyproline residues, and kahalalide J (2) also contains lysine. They have in common a β-hydroxy fatty acid, 3-hydroxy-9- methyldecanoic, previously encountered in kahalalide E. For kahalalide H (1) we succeeded in determining the sequential positions of the antipodal D- and L-phenylalanine. In common with the acyclic constituent of the alga, kahalalide G, the new compounds lack significant cytotoxicity.
AB - The sacoglossan mollusk Elysia rufescens elaborates six cyclic depsipeptides, kahalalides A- F. Its green algal diet (Bryopsis sp.) contains kahalalide G, which is an acyclic analogue of kahalalide F. Further analysis of the molluskan extract revealed two new acyclic peptides, kahalalide H (1) and kahalalide J (2), which share only four amino acids (leucine, phenylalanine, serine, and valine) with kahalalide F. Both contain aspartic acid and 4-hydroxyproline residues, and kahalalide J (2) also contains lysine. They have in common a β-hydroxy fatty acid, 3-hydroxy-9- methyldecanoic, previously encountered in kahalalide E. For kahalalide H (1) we succeeded in determining the sequential positions of the antipodal D- and L-phenylalanine. In common with the acyclic constituent of the alga, kahalalide G, the new compounds lack significant cytotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=0030982131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030982131&partnerID=8YFLogxK
U2 - 10.1021/np970045m
DO - 10.1021/np970045m
M3 - Article
AN - SCOPUS:0030982131
VL - 60
SP - 562
EP - 567
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -