Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock

Kazumasa Horikawa, Kazuyuki Fuji, Yuka Fukazawa, Shigenobu Shibata

    研究成果: Article

    4 引用 (Scopus)

    抄録

    Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock.

    元の言語English
    ページ(範囲)402-406
    ページ数5
    ジャーナルJournal of Pharmacological Sciences
    123
    発行部数4
    DOI
    出版物ステータスPublished - 2013

    Fingerprint

    Circadian Clocks
    Serotonin Receptors
    Receptor, Serotonin, 5-HT1A
    Cricetinae
    Serotonin 5-HT1 Receptor Agonists
    Serotonin
    serotonin 7 receptor
    osemozotan

    ASJC Scopus subject areas

    • Pharmacology
    • Molecular Medicine

    これを引用

    Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock. / Horikawa, Kazumasa; Fuji, Kazuyuki; Fukazawa, Yuka; Shibata, Shigenobu.

    :: Journal of Pharmacological Sciences, 巻 123, 番号 4, 2013, p. 402-406.

    研究成果: Article

    Horikawa, Kazumasa ; Fuji, Kazuyuki ; Fukazawa, Yuka ; Shibata, Shigenobu. / Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock. :: Journal of Pharmacological Sciences. 2013 ; 巻 123, 番号 4. pp. 402-406.
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