Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock

Kazumasa Horikawa, Kazuyuki Fuji, Yuka Fukazawa, Shigenobu Shibata

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock.

本文言語English
ページ(範囲)402-406
ページ数5
ジャーナルJournal of Pharmacological Sciences
123
4
DOI
出版ステータスPublished - 2013

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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