Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC

Yasuhito Taniguchi, Akihiro Yamaguchi, Atsushi Hijikata, Hideo Iwasaki, Kyoko Kamagata, Masahiro Ishiura, Mitiko Go, Takao Kondo*

*この研究の対応する著者

研究成果: Article査読

53 被引用数 (Scopus)

抄録

kaiABC, a gene cluster, encodes KaiA, KaiB and KaiC proteins that are essential to circadian rhythms in the unicellular cyanobacterium Synechococcus sp. strain PCC 7942. Kai proteins can interact with each other in all possible combinations. This study identified two KaiA-binding domains (CKABD1 and CKABD2) in KaiC at corresponding regions of its duplicated structure. Clock mutations on the two domains and kaiA altered the strength of CKABD-KaiA interactions assayed by the yeast two-hybrid system. Thus, interaction between KaiA and KaiC through CKABD1 and CKABD2 is likely important for circadian timing in the cyanobacterium.

本文言語English
ページ(範囲)86-90
ページ数5
ジャーナルFEBS Letters
496
2-3
DOI
出版ステータスPublished - 2001 5 11
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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