Two types of totally artificial red blood cell substitutes liposome embedded heme(L/H) and lipidheme/microsphere(LHM)

K. Kobayashi*, T. Kakizaki, T. Komatsu, Hiroyuki Nishide, E. Tsuchida

*この研究の対応する著者

研究成果: Article査読

抄録

Two types of totally artificial oxygen carriers were produced (1) by embedding synthetic lipidhemes (as oxygen carriers) in bilayers of liposomes as vehicles of lipidhemes(L/H) and (2) by covering clinically available fat droplets (triglyceride microspheres) with synthetic lipidhemes(LHM). Fat droplets were used as vehicles of lipidhemes. Their oxygen carrying ability in vivo was examined in beagles undergoing hemorrhagic shock. L/H delivered 15.7 to 19.2% of total oxygen delivery. From 12.7 to 24.4% of total oxygen consumption was from L/H. LHM delivered 11.6 to 7.3% of total oxygen delivery. From 13.1 to 16.4% of total oxygen consumption was from LHM. These totally synthetic red blood cell substitutes can be candidates for future clinical testing.

本文言語English
ページ(範囲)895-900
ページ数6
ジャーナルArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
22
3
出版ステータスPublished - 1994

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生体医工学
  • 生体材料
  • 血液学

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