Two types of totally synthetic oxygen carrier: Liposome embedded heme(L/H) and lipid heme microshere(LH-M)

K. Kobayashi*, Hiroyuki Nishide, E. Tsuchida

*この研究の対応する著者

研究成果: Article査読

抄録

Two types of totally artificial oxygen carrying substances are produced. In both systems, synthetic hemes are used as oxygen carrier. In liposome embedded heme system (L/H), synthetic hemes are embedded in bilayers of liposome as vehicles of hemes. In lipid heme microsphere system (LH-M), synthetic hemes are arranged to cover the surface of fat microspheres as vehicles of hemes. Design, physicochemical characteristics, solution properties, oxygen binding capacity in vitro of both materials were discussed. In vivo oxygen carrying ability of the L/H and LH-M was studied in dogs undergoing hemorrhagic shock by drawing 30 ml/kg of blood.

本文言語English
ジャーナルArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
22
5
出版ステータスPublished - 1994 11
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生体医工学
  • 生体材料
  • 血液学

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