Typing of X Chromosomes Bearing Tabby Allele in Mouse Preimplantation Embryos by Detection of a Microsatellite Marker

Ruby P A Valdivia, Tetsuo Kunieda*, Masahira Hattori, Yutaka Toyoda

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Tabby (Ta) is a semidominat allele of the locus on the mouse X chromosome, which causes a characteristic coat pattern and developmental defects in endocrinic glands. To establish a method for identifying the X chromosome bearing the Ta allele in early preimplantation embryos, we performed PCR amplification of an X chromosomal microsatellite marker locus from preimplantation embryos obtained from mating between XO female and XY male mice. The microsatellite marker locus was shown to be polymorphic between X chromosomes bearing the Ta and wild-type alleles. The amplification of the marker locus from early preimplantation embryos demonstrated that the Ta locus can be correctly typed by this method from embryos as little as 2 cells.

本文言語English
ページ(範囲)395-398
ページ数4
ジャーナルExperimental Animals
45
4
出版ステータスPublished - 1996 10
外部発表はい

ASJC Scopus subject areas

  • 動物科学および動物学
  • 獣医学(全般)

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