Underfilled Balloon-Expandable Transcatheter Aortic Valve Implantation With Ad Hoc Post-Dilation - Pulsatile Flow Simulation Using a Patient-Specific Three-Dimensional Printing Model

Masahiro Yamawaki, Kazuto Obama, Saeko Sasuga, Azuma Takahashi, Yoshiaki Ito, Mitsuo Umezu, Kiyotaka Iwasaki

    研究成果: Article

    1 引用 (Scopus)

    抜粋

    BACKGROUND: Underfilled transcatheter aortic-valve implantation with ad hoc post-dilation is a therapeutic option for patients with borderline annuli to avoid acute complication. The effects of this technique on valve leaflet behavior, hydrodynamic performances, and paravalvular leakage (PVL) using patient-specific three-dimensional (3D) aortic-valve models were investigated. Methods and Results: A female octogenarian patient was treated with this technique by using a 23-mm Sapien-XT. Patient-specific models were constructed from pre-procedure computed tomography (CT) data. Change in aortic annulus areas during systolic/diastolic phases and post-procedure stent areas were adjusted to those of the patient. The following was performed: (1) -3 cc initial and -2 cc underfilled post-dilation to the scale-down model by adjusting percent oversizing; and (2) -1 cc initial underfilling, nominal volume, and repeat nominal volume post-dilation using the patient-specific model. Underfilling was associated with higher %PVL. Observation using a high-speed camera revealed distorted leaflets after underfilled implantation, with a longer valve-closing time and smaller effective orifice areas, especially in the -3 cc underfilled implantation. Micro-CT analysis revealed that the transcatheter valves shifted to the opposite side of the large annulus calcification after post-dilation and reduced the malapposition there. CONCLUSIONS: Excessive underfilled implantation showed unacceptable acute hemodynamics. Abnormal leaflet motions after underfilled implantation raised concerns about durability. Flow simulations using patient-oriented 3D models could help to investigate hemodynamics, leaflet motions, and the PVL mechanism.

    元の言語English
    ページ(範囲)461-470
    ページ数10
    ジャーナルCirculation journal : official journal of the Japanese Circulation Society
    83
    発行部数2
    DOI
    出版物ステータスPublished - 2019 1 25

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    フィンガープリント Underfilled Balloon-Expandable Transcatheter Aortic Valve Implantation With Ad Hoc Post-Dilation - Pulsatile Flow Simulation Using a Patient-Specific Three-Dimensional Printing Model' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用