Unified synthesis of multiply arylated alkanes by catalytic deoxygenative transformation of diarylketones

Miki B. Kurosawa, Kenta Kato, Kei Muto, Junichiro Yamaguchi*

*この研究の対応する著者

研究成果: Article査読

抄録

A deoxygenative transformation of diarylketones leading to multiply arylated alkanes was developed. Diarylketones were reacted with diphenylphosphine oxide resulting in a phospha-Brook rearrangement, followed by palladium-catalyzed cross-couplings or a Friedel-Crafts type alkylation to afford the corresponding multiply arylated alkanes. A variety of diarylketones can be converted to multiply arylated alkanes such as diarylmethanes, tetraarylethanes, and triarylmethanes by reduction, dimerization, and arylation in one pot. Furthermore, a one-pot conversion from arylcarboxylic acids to diarylmethanes and tetraarylethanes, and a synthesis of tetraarylmethane and triphenylethane using sequential coupling reactions are also presented.

本文言語English
ページ(範囲)10743-10751
ページ数9
ジャーナルChemical Science
13
36
DOI
出版ステータスPublished - 2022 8月 22

ASJC Scopus subject areas

  • 化学 (全般)

フィンガープリント

「Unified synthesis of multiply arylated alkanes by catalytic deoxygenative transformation of diarylketones」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル