Updated therapeutic strategy for adult low-grade glioma stratified by resection and tumor subtype

Masayuki Nitta, Yoshihiro Muragaki, Takashi Maruyama, Hiroshi Iseki, Soko Ikuta, Yoshiyuki Konishi, Taichi Saito, Manabu Tamura, Michael Chernov, Atsushi Watanabe, Saori Okamoto, Katsuya Maebayashi, Norio Mitsuhashi, Yoshikazu Okada

研究成果: Article査読

25 被引用数 (Scopus)

抄録

The importance of surgical resection for patients with supratentorial low-grade glioma (LGG) remains controversial. This retrospective study of patients (n = 153) treated between 2000 to 2010 at a single institution assessed whether increasing the extent of resection (EOR) was associated with improved progression-free survival (PFS) and overall survival (OS). Histological subtypes of World Health Organization grade II tumors were as follows: diffuse astrocytoma in 49 patients (32.0%), oligoastrocytoma in 45 patients (29.4%), and oligodendroglioma in 59 patients (38.6%). Median pre-and postoperative tumor volumes and median EOR were 29.0 cm3 (range 0.7-162 cm3) and 1.7 cm3 (range 0-135.7 cm3) and 95%, respectively. Five- and 10-year OS for all LGG patients were 95.1% and 85.4%, respectively. Eight-year OS for diffuse astrocytoma, oligoastrocytoma, and oligodendroglioma were 70.7%, 91.2%, and 98.3%, respectively. Five-year PFS for diffuse astrocytoma, oligoastrocytoma, and oligodendroglioma were 42.6%, 71.3%, and 62.7%, respectively. Patients were divided into two groups by EOR ≥90% and <90%, and OS and PFS were analyzed. Both OS and PFS were significantly longer in patients with ≥90% EOR. Increased EOR resulted in better PFS for diffuse astrocytoma but not for oligodendroglioma. Multivariate analysis identified age and EOR as parameters significantly associated with OS. The only parameter associated with PFS was EOR. Based on these findings, we established updated therapeutic strategies for LGG. If surgery resulted in EOR <90%, patients with astrocytoma will require second-look surgery, whereas patients with oligodendroglioma or oligoastrocytoma, which are sensitive to chemotherapy, will be treated with chemotherapy.

本文言語English
ページ(範囲)447-454
ページ数8
ジャーナルNeurologia Medico-Chirurgica
53
7
DOI
出版ステータスPublished - 2013
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 臨床神経学

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