Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Ryoko Kibe, Shin Kurihara, Yumi Sakai, Hideyuki Suzuki, Takushi Ooga, Emiko Sawaki, Koji Muramatsu, Atsuo Nakamura, Ayano Yamashita, Yusuke Kitada, Masaki Kakeyama, Yoshimi Benno, Mitsuharu Matsumoto

研究成果: Article査読

115 被引用数 (Scopus)

抄録

Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.

本文言語English
論文番号4548
ジャーナルScientific reports
4
DOI
出版ステータスPublished - 2014 4 1
外部発表はい

ASJC Scopus subject areas

  • 一般

フィンガープリント

「Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル