TY - JOUR
T1 - Uric acid levels in tissues and plasma of mice during aging
AU - Iwama, Mizuki
AU - Kondo, Yoshitaka
AU - Shimokado, Kentaro
AU - Maruyama, Naoki
AU - Ishigami, Akihito
PY - 2012/8
Y1 - 2012/8
N2 - Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging. UA levels in the adrenal glands, heart, and spleen increased with aging until 30 months of age. Similarly, UA levels in the liver, kidneys, pancreas, and testes increased until the mice were 24 months old. UA levels also rose in the lungs and skeletal muscles from 3 to 6 months and 6 to 12 months, respectively, and then remained at almost the same levels until 30 months of age. In the skin, UA decreased from 3 to 6 months and then stayed nearly constant until 30 months of age. Moreover, the small intestines and plasma had quite stable UA levels during aging. Thus, our assessment of 11 tissue types from mice showed that the UA levels increased in most tissues during aging.
AB - Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging. UA levels in the adrenal glands, heart, and spleen increased with aging until 30 months of age. Similarly, UA levels in the liver, kidneys, pancreas, and testes increased until the mice were 24 months old. UA levels also rose in the lungs and skeletal muscles from 3 to 6 months and 6 to 12 months, respectively, and then remained at almost the same levels until 30 months of age. In the skin, UA decreased from 3 to 6 months and then stayed nearly constant until 30 months of age. Moreover, the small intestines and plasma had quite stable UA levels during aging. Thus, our assessment of 11 tissue types from mice showed that the UA levels increased in most tissues during aging.
KW - Aging
KW - Mouse tissue
KW - Uric acid
KW - Uricase
UR - http://www.scopus.com/inward/record.url?scp=84864962281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864962281&partnerID=8YFLogxK
U2 - 10.1248/bpb.b12-00198
DO - 10.1248/bpb.b12-00198
M3 - Article
C2 - 22863939
AN - SCOPUS:84864962281
VL - 35
SP - 1367
EP - 1370
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 8
ER -