Uric acid levels in tissues and plasma of mice during aging

Mizuki Iwama, Yoshitaka Kondo, Kentaro Shimokado, Naoki Maruyama, Akihito Ishigami*

*この研究の対応する著者

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Here we quantified the uric acid (UA) levels in 11 tissues and plasma of C57BL/6 male mice to track its turnover during 3 to 30 months of aging. UA levels in the adrenal glands, heart, and spleen increased with aging until 30 months of age. Similarly, UA levels in the liver, kidneys, pancreas, and testes increased until the mice were 24 months old. UA levels also rose in the lungs and skeletal muscles from 3 to 6 months and 6 to 12 months, respectively, and then remained at almost the same levels until 30 months of age. In the skin, UA decreased from 3 to 6 months and then stayed nearly constant until 30 months of age. Moreover, the small intestines and plasma had quite stable UA levels during aging. Thus, our assessment of 11 tissue types from mice showed that the UA levels increased in most tissues during aging.

本文言語English
ページ(範囲)1367-1370
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
35
8
DOI
出版ステータスPublished - 2012 8
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

フィンガープリント

「Uric acid levels in tissues and plasma of mice during aging」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル