V1 Projection Zone Signals in Human Macular Degeneration Depend on Task Despite Absence of Visual Stimulus

Yoichiro Masuda*, Hiromasa Takemura, Masahiko Terao, Atsushi Miyazaki, Shumpei Ogawa, Hiroshi Horiguchi, Satoshi Nakadomari, Kenji Matsumoto, Tadashi Nakano, Brian A. Wandell, Kaoru Amano

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Identifying the plastic and stable components of the visual cortex after retinal loss is an important topic in visual neuroscience and neuro-ophthalmology.1–5 Humans with juvenile macular degeneration (JMD) show significant blood-oxygen-level-dependent (BOLD) responses in the primary visual area (V1) lesion projection zone (LPZ),6 despite the absence of the feedforward signals from the degenerated retina. Our previous study7 reported that V1 LPZ responds to full-field visual stimuli during the one-back task (OBT), not during passive viewing, suggesting the involvement of task-related feedback signals. Aiming to clarify whether visual inputs to the intact retina are necessary for the LPZ responses, here, we measured BOLD responses to tactile and auditory stimuli for both JMD patients and control participants with and without OBT. Participants were instructed to close their eyes during the experiment for the purpose of eliminating retinal inputs. Without OBT, no V1 responses were detected in both groups of participants. With OBT, to the contrary, both stimuli caused substantial V1 responses in JMD patients, but not controls. Furthermore, we also found that the task-dependent activity in V1 LPZ became less pronounced when JMD patients opened their eyes, suggesting that task-related feedback signals can be partially suppressed by residual feedforward signals. Modality-independent V1 LPZ responses only in the task condition suggest that V1 LPZ responses reflect task-related feedback signals rather than reorganized feedforward visual inputs.

本文言語English
ページ(範囲)406-412.e3
ジャーナルCurrent Biology
31
2
DOI
出版ステータスPublished - 2021 1 25
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)

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