Variations in carotid arterial compliance during the menstrual cycle in young women

Koichiro Hayashi*, Motohiko Miyachi, Natsuki Seno, Kouki Takahashi, Ken Yamazaki, Jun Sugawara, Takashi Yokoi, Sho Onodera, Noboru Mesaki

*この研究の対応する著者

研究成果査読

63 被引用数 (Scopus)

抄録

The effect of menstrual cycle phase on arterial elasticity is controversial. In 10 healthy women (20.6 ± 1.5 years old, mean ±s.d.), we investigated the variations in central and peripheral arterial elasticity, blood pressure (carotid and brachial), carotid intima-media thickness (IMT), and serum oestradiol and progesterone concentrations at five points in the menstrual cycle (menstrual, M; follicular, F; ovulatory, O; early luteal, EL; and late luteal, LL). Carotid arterial compliance (simultaneous ultrasound and applanation tonometry) varied cyclically, with significant increases from the values seen in M (0.164 ± 0.036 mm2 mmHg-1) and F (0.171 ± 0.029 mm2 mmHg-1) to that seen in the O phase (0.184 ± 0.029 mm2 mmHg -1). Sharp declines were observed in the EL (0.150 ± 0.033 mm2 mmHg-1) and LL phases (0.147 ± 0.026 mm 2 mmHg-1; F = 8.51, P < 0.05). Pulse wave velocity in the leg (i.e. peripheral arterial stiffness) did not exhibit any significant changes. Fluctuations in carotid arterial elasticity correlated with the balance between oestradiol and progesterone concentrations. No significant changes were found in carotid and brachial blood pressures, carotid artery lumen diameter, or IMT throughout the menstrual cycle. These data provide evidence that the elastic properties of central, but not peripheral, arteries fluctuate significantly with the phases of the menstrual cycle.

本文言語English
ページ(範囲)465-472
ページ数8
ジャーナルExperimental Physiology
91
2
DOI
出版ステータスPublished - 2006 3
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 栄養および糖尿病
  • 生理学(医学)

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